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Category: Meetings || File ID: 77 || Last changed on: 2011-06-21 10:33:49+01

Mouse models for human diseases

A meeting organised by the CASIMIR consortium and the European Commission

The Royal Society London, May 19-21 2010

Report from the European Commission on the use of the mouse to understand human disease based on Day 3 of the meeting:


http://www.ec.europa.eu/research/health/pdf/summary-report-25082010_en.pdf (Local copy)


DAY 1 WEDNESDAY 19TH MAY


Workshop 1: Tools and Resources for the creation and validation of mouse models

Introduction and Keynote



Chair: Paul Schofield, University of Cambridge

09:15 Introduction Wolfgang Wurst, Helmholtz Institute Munich,
09:30 Keynote Speaker Sir Leszek Borysiewicz, CEO Medical Research
Council, UK

Session 1: International and Collaborative Projects in mouse genetics



10:00 The International knockout Mouse Consortium and newly available resources
Bill Skarnes, Wellcome Trust Sanger Institute, Hinxton

10:30 Genetic Reference Panels of Mice: Powerful New Resources for Personalized and Preventive Health Care using a Systems Approach
Rob Williams, University of Tennessee Health Science Center

11:00 Coffee

Session 2: Use of mouse genetics to understand complex traits



Chair: Klaus Schughart, Helmholtz Centre for Infection Research, Braunschweig

11:20 The Jackson Laboratory Ageing Programme
Luanne Peters, The Jackson Laboratory, Bar Harbor

11:50 Cross-species genetics of neurobehavioural traits; relevance to psychiatric disorders
Martien Kas, University Medical Centre, Utrecht

12:20 General Discussion

12:45 Lunch

Integrating and analysing phenotypic data



Session 3: Informatics of phenotyping



Chair: John Hancock, MRC Harwell

13:45 Integrating phenotype data with Mouse Genome Informatics
Janan Eppig, The Jackson Laboratory, Bar Harbor

14:05 Phenotype database interoperability, integration and resource scaling
Damian Smedley, European Bioinformatics Institute, Hinxton

14:25 Semantic challenges in mouse and human phenotype ontology development
John Hancock, MRC Harwell

14:45 Tea

15:15 Integrating human and mouse phenotype ontologies
Peter Robinson, Charite Hospital, Berlin

15.35 Discussion

Session 4: Sharing of data and bioresources



Chair. Paul Schofield, University of Cambridge

16:05 Intellectual property issues and the “Mouse Commons”
Tania Bubela, University of Alberta

16:35 Business models and challenges for bioresource repositories
Tom Weaver, The Mary Lyon Centre, MRC Harwell.

17:05 Infrafrontier and infrastructures for mouse models research
Martin Hrabe de Angelis, Helmholtz Institute Munich

17:35 Discussion

18.00 EATRIS European Advanced Translational Research Infrastructure in Medicine.
Rudi Balling, IDC Systems Biology, University of Luxembourg

18.20 Discussion

18.30 Drinks Reception – The Marble Hall

19.15 Conference Dinner – The Dining Room


DAY 2 THURSDAY 20TH MAY




Session 5: Mouse phenotyping; the state of the art



Chair: Martin Hrabe de Angelis, Institute of Experimental Genetics, Helmholtz Institute, Munich

9:00 High-throughput and high-resolution strategies for imaging mouse embryonic malformations
Shoumo Bhattacharya, University of Oxford

09:20 NMR and Mass spectroscopic approaches to metabolomics in man and mouse
Jules Griffin, University of Cambridge

09:40 Challenges in high-throughput phenotyping
Steve Brown, MRC Harwell

10:00 Discussion

10:15 Coffee

Session 6 Challenges for modelling human disease



Chair: Stephen O’Rahilly, University of Cambridge

10:35 Metabolic disease models in the mouse, and translation to human disease
Fatima Bosch, Universite Autonoma de Barcelona

10:55 Mouse models for type 2 diabetes and obesity
Roger Cox, MRC Harwell

11.15 Discussion

Chair: Rudi Balling, University of Luxembourg .

11:30 Tumor necrosis factor and inflammatory disease
George Kollias, Fleming Institute, Athens

11:50 Mouse models and stem cell therapy for type 1 diabetes
Anne Cooke, University of Cambridge

12:10 Discussion

12: 30 Lunch

Chair: Wolfgang Wurst, Institute of Developmental Genetics
Helmholtz Institute, Munich

13:30 Human Genetics of Parkinson Disease
Thomas Gasser, Hertie Institut, University of Tübingen

13:50 Mouse models of complex neuropsychiatric disorders: from phenotype to gene or gene to phenotype
David Collier, Institute of Psychiatry, Kings College, London

14:10 Discussion

Chair: Alex Nikitin, Cornell University

14:30 Our Inner Mouse: Genomic insights from mouse mammary cancer models to guide pre-clinical testing
Jeff Green, National Cancer Institute, Bethesda.

14:50 Preclinical utility of GEM models of breast cancer
Jos Jonkers Netherlands Cancer Institute, Amsterdam, The Netherlands

15:20 Genetically engineered mouse models of cancer in preclinical trials to guide/incentivize clinical trials
Doug Hanahan, Swiss Institute for Experimental Cancer Research, Lausanne.

15:40 Discussion

16.00 Tea

16:20 International Mouse Phenotyping Consortium
Mark Moore, The Wellcome Trust

16:40 The Future of International Mouse Resources
Allan Bradley, Wellcome Trust Sanger Institute

17:00 James Battey, Director NIDCD, NIH.

17:20 Discussion

DAY 3 FRIDAY 21ST MAY


Are mice relevant models for human disease?


Satellite workshop organised by the European Commission
Aims of the meeting
This satellite meeting is aimed at bringing together mouse geneticists, clinicians and industry representatives to identify approaches for development of optimal mouse models for human disease to facilitate clinical research and drug development.

SESSION A - WHAT ARE THE CLINICAL AND INDUSTRY
REQUIREMENTS FOR MOUSE MODELS?



9.00-9.10. Welcome speech: Irene Norstedt, European Commission

9.10-9.40 Keynote speech: Aris Economides, Regeneron Pharmaceuticals, USA

9.40-10.45. Panel discussions
Panel participants (each panel participant is given 5-10 minutes to present his/her view):
Chair: Eero Vuorio, University of Turku, Finland
Tania Bubela, University of Alberta, Canada
John Hickman, Institut de Recherches Servier, France
Leisa Johnson, Genentech, USA
Tom Shepherd, CXR Biosciences Ltd., UK
Malcolm Skingle, GlaxoSmithKline, UK
Steve Wedge, Astra-Zeneca, UK
Sir Magdi Yacoub, Imperial College London, UK

10.45-11.00. Coffee break

10.45-12.30. Panel discussions (continuation)

12.30 – 13.30 Lunch

SESSION B - HOW TO OPTIMISE MOUSE MODELS FOR HUMAN
DISEASE



13.30-14.00. Keynote speech: Pier Paolo Pandolfi, Harvard Medical School, USA

14.00-15.00. Panel discussions
Panel participants (each panel participant is given 5-10 minutes to present his/her view):
Chair: Beatrice Silva Lima, University of Lisbon, Portugal
Stuart Cook, Imperial College London, UK
Michael Hayden, University of British Columbia, USA
Alexander Nikitin, Cornell University, USA
Igor Pogribny, National Center for Toxicological Research/FDA, USA
Nadia Rosenthal, EMBL Monterotondo, Italy
Rosalba Sacca, Pfizer Inc., USA
Michael Schneider, National Heart and Lung Institute, UK

15.00-15.15. Tea

15.15-16.45. Panel discussions (continuation)

16.45-17.00. Conclusions:
Beatrice Silva Lima, University of Lisbon, Portugal
Eero Vuorio, University of Turku, Finland
Jacques Remacle, European Commission


END OF MEETING
Additional material:

peters.pdf

williams.pdf

green.pdf

gasser.pdf

robinson.pdf

brown.pdf

borysiewicz.pdf

hancock.pdf

kolias.pdf

shoumo.pdf

kas.pdf

smedley.ppt

balling.pdf

battey.pptx

griffin.ppt

jonkers.pdf

moore.pptx

bubela.pdf

skarnes.pdf

collier.pdf

summary-report-25082010 en.pdf
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